There are specific situations where the score will change what pitchers do. With a big lead, pitchers may be less afraid to challenge hitters, a strategy which often results in more strikeouts and hits, but fewer walks. Similarly, in close games pitchers may be reluctant to throw the ball down the middle of the plate, a strategy which would result in fewer home runs, but possibly more walks. Even if we accept this at face value and assume that all pitchers have a sufficient breadth of approaches and sufficient command to implement these strategies, the impact of these approaches over the course of a season or even a career is probably somewhat limited.